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LocationKirksville is located in north Missouri, and can be reached by air, rail or highway. For a map of the area see Kirksville Area Map.Kirksville Regional Airport ![]() With a 6,000-foot hard surface runway, the Kirksville Regional Airport accommodates two daily flights to and from St. Louis Lambert Airport. Call 660-627-0100 or visit www.kirksvillecity.com for commercial flight information. Purchase tickets at www.airchoiceone.com. Amtrak ![]() The Amtrak station is only 12 miles south of Kirksville in La Plata, Missouri. Two passenger trains (eastbound and westbound Southwest Chief), stop daily to board and drop off passengers. Call 800-USA-RAIL or purchase tickets at www.amtrak.com. Driving ![]() If you are driving to Kirksville, travel on newly four-laned Highway 63. Car Rentals in Kirksville, MO:
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